carvacrol timol orégano

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Thymol and Carvacrol also have antibacterial properties as pure substances. The site is secure. 16 (11), 1286–1295. HIPÓTESIS/OBJETIVOS: Se investigó la eficacia in vitro del aceite de orégano, el aceite de tomillo y sus principales componentes fenólicos contra los aislados bacterianos y fúngicos asociados con la otitis externa canina. En uso interno Antibacteriano. J. Dr Behcet Uz Child. Anticancer Drugs 26 (8), 813–823. Kelly and SH-SY5Y neuroblastoma cells also exhibited a reduced proliferation rate after exposure to carvacrol (Kocal and Pakdemirli, 2020). Res. Carvacrol Exhibits Anti-oxidant and Anti-inflammatory Effects against 1, 2-dimethyl Hydrazine Plus Dextran Sodium Sulfate Induced Inflammation Associated Carcinogenicity in the colon of Fischer 344 Rats. PI3k belongs to a family of lipid kinases, involved in extracellular signals transduction and cell growth promotion (Wullschleger et al., 2006; Alzahrani, 2019). Biomed. Los cromatogramas fueron elaborados en: Instituto de Investigación en Bioquímica y Biología Molecular de la UNALM, 2014. In a later study, Zeng et al. Cell cycle involvement in cancer treatment with carvacrol and thymol. doi:10.1016/j.tox.2012.10.026, Liang, W. Z., and Lu, C. H. (2012). [5] The essential oil of thyme subspecies contains between 5% and 75% of carvacrol, while Satureja (savory) subspecies have a content between 1% and 45%. Federal government websites often end in .gov or .mil. Thus, it is necessary to consider the studies already carried out for these compounds before conducting new primary studies on this topic, in order to evolve the research stages to the next level of drug development: in vivo studies and clinical trials. Thus, the dose-response relationship must be considered in more detail, so that further studies in more advanced stages are developed to assess the antitumor effects of these compounds. B., et al. Cancer Biol. Esto asegura que no se ha producido pérdidas durante el proceso de análisis. (2013). Front. León-Rodríguez, A. de, Escalante-Minakata, P., Jiménez-García, M. I., Ordoñez-Acevedo, L. G., Flores Flores, J. L. and Barba de la Rosa, A. P., Food Technology and Biotechnology, 2008, Volume 46, Number 4, pages 448-455 (, parte superior da página, em frente ao título do artigo, condições normais de temperatura e pressão, Referências e avisos gerais sobre esta caixa, «Carvacrol data sheet from Sigma-Aldrich», http://www.liu.edu/Brooklyn/About/News/Press-Releases/2012/April/BK-PR-Apr25-2012.aspx, http://www.hort.purdue.edu/newcrop/proceedings1993../V2-628.html, http://www.herbapolonica.pl/magazines-files/2733672-art.3.pdf, Journal of Radioanalytical and Nuclear Chemistry, https://pt.wikipedia.org/w/index.php?title=Carvacrol&oldid=57189741, !Artigos que necessitam de esclarecimento, !Artigos que incorporam texto da Encyclopædia Britannica, Atribuição-CompartilhaIgual 3.0 Não Adaptada (CC BY-SA 3.0) da Creative Commons, 25 bactérias e estirpes periodontopáticas diferentes, Este artigo incorpora texto (em inglês) da. }. (2016). Palabras clave: Aceite esencial, Timol, Carvacrol, Orégano, Origanum, HS-SPME-GC-MS. Recibido: 17/08/2020 3. Antimicrobial effects of cinnamon essential oil and cinnamaldehyde combined with EDTA against canine otitis externa pathogens. doi:10.1155/2018/9049252, Wang, Y., He, Q.-Y., and Chiu, J.-F. (2014). Final approval of the completed manuscript: AG and DT. 64, 281–290. Turk J. Biol. Even after almost two decades of research in this field, there has been no progress in research in humans, possibly due limitations of preclinical studies and the lack of knowledge about pharmacokinetics and toxicity of carvacrol and thymol. Available at: https://www.who.int/publications/i/item/who-report-on-cancer-setting-priorities-investing-wisely-and-providing-care-for-all (Acesseced November 13, 2020). Life Sci. Cancer 69 (7), 1075–1087. var w = d.getElementsByTagName('script')[0]; Carvacrol Timol 80%. 9, 2297–2304. Significance and impact of study: In the wake of rising antimicrobial resistance, we envisage that carvacrol and thymol could be used to prevent biofilm formation by UPEC and to reduce its virulence. An official website of the United States government. doi:10.7287/peerj.9626v0.1/reviews/1, Soković, M., Glamoclija, J., and Ciric, A. Thymol also caused a decrease in cell viability of prostate cancer (PC-3 cell line), and provoked cytotoxic effects (Pathania et al., 2013; Yeh et al., 2017; De La Chapa et al., 2018). Origanum majorana e Origanum dictamnus são ricas em carvacol, 50% e 60-80% respectivamente. doi:10.1016/S1470-2045(18)30094-9, Whitfield, J. Wu, Q., Wu, W., Fu, B., Shi, L., Wang, X., and Kuca, K. (2019). 35 (2011), 735–742. Ultrastructural Pathol. A principal via metabólica é a esterificação do grupo fenólico com ácido sulfúrico e ácido glucurónico. The inhibition of cell proliferation and apoptosis on MDA-MB231 and MCF-7 cell lines occurred via the mitochondrial pathway and induction of oxidative damage to DNA through Bax/Bcl-2 modulation, decreased levels of procaspase-8, -9, -3, increased levels of cleaved caspase-3 and ROS, and also cell cycle arrest at S-phase (Jamali et al., 2018). Physiol. (2002). The Mechanism of Carvacrol-Evoked [Ca2+]i Rises and Non-ca2+-triggered Cell Death in OC2 Human Oral Cancer Cells. doi:10.1023/b:cyto.0000039917.60348.45. ACEITE DE ORÉGANO 150 MG: Nuestro Aceite de Orégano contiene Carvacrol, Timol y otros Terpenos, antisépticos y antioxidantes naturales, que promueven la Salud Digestiva y Respiratoria. Chem. Caspase-9 as a Therapeutic Target for Treating Cancer. In Asia, the continent with the largest number of publications on the subject, the use of traditional, popular medicine continues to grow (De Boer and Cotingting, 2014) due to the low costs, easy access, the frequent reduced side effects and toxicity, and their better biodegradable properties (Soković et al., 2013). This corroborated the findings of Wang et al. Wong, R. J., Ahmed, A., and Gish, R. G. (2015). Tanto el carvacrol como el timol tienen la misma fórmula química (C10H14O), pero tienen estructuras ligeramente diferentes. Med. Cytotechnology 64 (1), 43–51. Asian Pac. Sorgo (Sorghum bicolor L. Moench) tratados con timol y carvacrol extraídos de orégano (Lippia graveolens Kunth) mediante métodos químicos, con el fin de obtener fitorreguladores naturales e implementar esta alternativa para minimizar efectos negativos ocasionados por la utilización de compuestos químicos perjudiciales para el . en los pies. doi:10.2174/156652411800615162, Belyi, V. A., Ak, P., Markert, E., Wang, H., Hu, W., Puzio-Kuter, A., et al. Food Chem. Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-independent Human Prostate Cancer Cells via Inhibition of Notch Signaling. Food Sci. Tanto el aceite de orégano como el de tomillo son muy ricos en timol y carvacrol, y los investigadores de la Universidad de Gante sostienen que es capaz de antagonizar la colonización por bacterias del tipo Shigella spp. The Staphylococcus aureus bacterium is one of the most . [6] Daña la membrana celular e inhibe la proliferación . (2012). 266, 118894. doi:10.1016/j.lfs.2020.118894, Li, S., Zhao, H., and Bao, L. (2019). Serum Alphal-Fucosidase Enzyme Activity in Ovarian and Other Female Genital Tract Tumors. 32 (6), 1090–1097. Cancer Res. É extraída do óleo de Origanum usando uma solução de potassa a 50%. Oregano oil, thyme oil, carvacrol and thymol showed good in vitro bactericidal and fungicidal activity against 100 isolates from dogs with otitis externa, including some highly drug-resistant isolates. One hundred bacterial and fungal isolates, including meticillin-susceptible Staphylococcus pseudintermedius (n = 10), meticillin-resistant S. pseudintermedius (n = 10), β-haemolytic Streptococcus spp. HIPÓTESE/OBJETIVOS: Investigou-se a eficácia in vitro do óleo de orégano, óleo de tomilho e seus principais componentes fenólicos contra isolados bacterianos e fúngicos associados com otite externa canina. Oncogene 18 (10), 1781–1787. Food Sci. Un sinónimo de este compuesto es cymophenol. doi:10.3892/or.2012.1877, Abdel-Aleem, H., Ahmed, A., Sabra, A. M., Zakhari, M., Soliman, M., and Hamed, H. (1996). Um ensaio de cinética de tempo de morte foi realizado para confirmar a atividade bactericida e fungicida dos óleos e seus componentes fenólicos. FREE delivery Fri, Dec 16 on $25 of items shipped by . Fungicides—Showcases of Integrated Plant Disease. (2017). 491 (2), 530–536. There is, therefore, an ongoing search for substances that can be used to develop more effective treatments, with less side effects, to use against cancer; one promising group of substances are natural products (NPs). Aplicación del método a muestras de orégano. J. Clin. doi:10.2174/1389202917666160808125645, Baj, T., Biernasiuk, A., Wróbel, R., and Malm, A. Hence, positive expression of caspases increases tumor sensitization to treatment (Hensley et al., 2013) (Figure 6). Biomed. Targeting HIF-1 for Cancer Therapy. Resumen. Epub 2019 May 21. Product details Is Discontinued By Manufacturer ‏ : ‎ No Product Dimensions ‏ : ‎ 2 x 1.5 x 3.5 inches; 1.34 Ounces Date First Available ‏ : ‎ March 14, 2017 Cancer Lett. TABLE 2. Phytochemicals as Lead Comp. (2016). doi:10.1038/modpathol.3800066, Georgakilas, A. G., Martin, O. Gelatinolytic Activity of Matrix Metalloproteinase-2 and -9 in Oesophageal Carcinoma; a Study Using In Situ Zymography. Cancer Res. It controls cell growth, proliferation, differentiation and apoptosis, and represents one of the main signaling pathways involved in extracellular signals transduction (Binétruy et al., 2007; Kim and Choi, 2015; Li et al., 2018). The Bioactivity and Toxicological Actions of Carvacrol. Epub 2019 Nov 15. Rev. 10. doi:10.1371/journal.pmed.1003583, Pakdemirli, A., Karaca, C., Sever, T., Daşkin, E., Leblebici, A., Yiğitbaşi, T., et al. [6] Origanum majorana (marjoram) and Dittany of Crete . doi:10.1016/j.jhep.2018.07.004, Wang, J., Su, B., Zhu, H., Chen, C., and Zhao, G. (2016). J. Cel Physiol. doi:10.1016/j.tiv.2015.02.006, Low, H. B., and Zhang, Y. 7. Data acquisition: LS and LP. Para el desarrollo del método cromatográfico, se requiere una separación de los picos; se evaluó la resolución de los picos de timol y carvacrol. doi:10.1016/j.fct.2013.08.037, Pernas, S., Tolaney, S. M., Winer, E. P., and Goel, S. (2018). De la muestra de 200 mg/L del aceite esencial disueltos en ACN:H2O (80:20), se requirió una dilución 1:10. 9 (5), 294–299. Moreover, India and China have, historically, made important contributions to knowledge about medicinal plants, being responsible for some of the most ancient reports about this issue, that were written approximately 5,000 and 4,000 years ago, respectively (Wiart, 2007; Kelly, 2009). In contrast, 30% (n = 3) record random allocation of the animals in the study (Figure 4). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Koyama, H., Iwata, H., Kuwabara, Y., Iwase, H., Kobayashi, S., and Fujii, Y. Aceite esencial de orégano: un potencial aditivo alimentario. Se utilizó 200 mg/L de muestra del aceite esencial disueltos en ACN:H O (80:20). Hintergrund: (2004). Am Fam Physician 2006; 74: 1,510-1,516. Carvacrol Induces Mitochondria-Mediated Apoptosis via Disruption of Calcium Homeostasis in Human Choriocarcinoma Cells. Signal Integration by JNK and P38 MAPK Pathways in Cancer Development. Methoden und materialien: Nelson, R. L. (1982). s.type = 'text/javascript'; DNA-protective Effects of Two Components of Essential Plant Oils Carvacrol and Thymol on Mammalian Cells Cultured In Vitro. MATÉRIELS ET MÉTHODES: La sensibilité antimicrobienne a été testée par microdilution sur plaque pour déterminer la concentration minimale inhibitrice et les concentrations bactéricides/fongicides (MICs, MBCs et MFCs). Chemical Composition and In Vitro Activity of Origanum Vulgare L., Satureja Hortensis L., Thymus Serpyllum L. And Thymus Vulgaris L. Essential Oils towards Oral Isolates of Candida Albicans and Candida Glabrata. A Useful Marker in the Diagnosis of Hepatocellular Carcinoma. Colorectal cancer (Caco-2 cell line) also exhibited reduced cell viability and a significant increase of early apoptotic cells after carvacrol incubation (115 μM) (Llana-Ruiz-Cabello et al., 2014). doi:10.3906/sag-1907-173. Asia (51.9%) was the continent with the largest number of publications on the subject, followed by Europe (33.7%), the Americas (9.3%) and Africa (5.1%), with a greater trend of publications on this subject in the last three years (Supplementary Figure S1). (2018). (2004) identificaram proporção muito superior de timol do que carvacrol em O. vulgare L. (orégano) cultivado na região sul do Rio Grande do Sul. Caspases and Cancer. Moreover, genotoxic effects have been shown to be exhibited by carvacrol (Günes-Bayir et al., 2018) and thymol (Günes-Bayir et al., 2018), and it was also shown that a high concentration of carvacrol (460 µM) exhibited mutagenic and genotoxic effects causing DNA damage (Llana-Ruiz-Cabello et al., 2015). Carvacrol and Human Health: A Comprehensive Review. Epidemiological study of dogs with otitis externa in Cape Breton, Nova Scotia. (n = 20), Pseudomonas aeruginosa (n = 20; including 10 isolates resistant to one or two antimicrobials), Proteus mirabilis (n = 20) and Malassezia pachydermatis (n = 20) from dogs with otitis externa were used. 125, 198–209. Expression of Bcl-2 and P53 in Induction of Esophageal Cancer Cell Apoptosis by ECRG2 in Combination with Cisplatin. El timol (2- iso propil-5-methil-fenol) es una sustancia cristalina incolora con un olor característico que está presente en la naturaleza en los aceites esenciales del tomillo o del orégano. (2011). MMP‐2 and MMP‐9 as Prognostic Markers for the Early Detection of Urinary Bladder Cancer. El timol pertenece al grupo de los terpenos. ¿Qué es el carvacrol? Costa LV, Moreira JMAR, Menezes IG, Dutra V, de Almeida ADBPF. 5. 14, 2535–2547. Cancer Treat. Carvacrol: es un fenol que se encuentra en mayor abundancia en el aceite de orégano. doi:10.1016/j.cld.2015.01.005. Se determinó la concentración de los componentes de la muestra a partir de la curva de calibración por regresión lineal y luego se llevó a masa de la hoja. There is also still a wide variation in the doses used, requiring the establishment of a consensus in respect of defining potentially effective and safe doses. CONCLUSIONES E IMPORTANCIA CLÍNICA: el aceite de orégano, el aceite de tomillo, el carvacrol y el timol mostraron una buena actividad bactericida y fungicida in vitro frente a 100 aislados de perros con otitis externa, incluidos algunos aislados altamente resistentes a los fármacos. Cancer Biol. Methodology (CPMP/ICH/281/95) London: ICH Topic Q2B, Validation of Analytical Procedures. 92, 491–500. Carvacrol and its isomer, thymol, are natural compounds that act against several diseases, including cancer. Am. Cancer Sci. } Para P. aeruginosa y M. pachydermatis, los valores de MIC90 variaron de 0,09 a 0,25% (800-2,292 μg/mL). Drug Chem. IUBMB Life 71 (2), 166–176. In in vivo studies, on the other hand, the effect of carvacrol has been predominantly studied against hepatocarcinoma, with few studies for breast and colon cancer. (2015) reported cytotoxic effects of carvacrol on gastric cancer (AGS cell line) significantly reducing cell viability in a manner dependent on concentration. doi:10.1016/j.semcancer.2019.07.009, Arigesavan, K., and Sudhandiran, G. (2015). A hipótese foi de que os principais componentes fenólicos teriam maior atividade antimicrobiana quando comparados com o óleo essencial relativo. Biol. doi:10.3748/wjg.v8.i3.464, Akalin, G., and Incesu, Z. Thymol also showed concentration-dependent cytotoxic effects and reduced the proliferation of Caco-2 cells (Horváthová et al., 2006). (2014). Med. Cancer Res. J. Pharmacol. Biomed. Cancer Ther. The via extracellular signal-regulated kinases (ERK) protein, and mitogen-activated protein kinases (p38) apoptotic pathways may also be involved (Yin et al., 2012). Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All. TABLE 1. 4. Cancer 36 (16), 2164–2170. Conclusions et importance clinique: Natural Products: an Evolving Role in Future Drug Discovery. 22 (5), 41–53. doi:10.1155/2016/1469693, Mari, A., Mani, G., Nagabhishek, S. N., Balaraman, G., Subramanian, N., Mirza, F. B., et al. (2015). 4. Targeting Vascular Endothelial Growth Factor and Angiogenesis for the Treatment of Colorectal Cancer. For the colorectal cancer model, HCT116 xenograft was injected (i.p.) Este parámetro muestra la proximidad entre el valor experimental y el valor real. doi:10.1007/s10787-019-00583-8, Chan, H., Ho, J., Liu, X., Zhang, L., Wong, S. H., Chan, M., et al. Os efeitos citotóxicos do carvacrol podem fazer dele um agente antisséptico e antimicrobiano efectivo. Frente a dolores musculares o de . Discov. (2016). (2005). In vivo, Suntres et al. Mercado Libre Argentina - Donde comprar y vender de todo. Detailed description of the studies that used thymol, included in the systematic review. (2018). CDK4/6 Inhibition in Breast Cancer: Current Practice and Future Directions. (2014) also evaluated the effect of carvacrol pre- and post-treatment on a DEN-induced hepatocarcinogenesis rat model and observed a stability in tumor marker levels, a reduced mast cell density and inhibition of cell proliferation. doi:10.7314/apjcp.2014.15.11.4519, Liu, W.-W., Zeng, Z.-Y., Wu, Q.-L., Hou, J.-H., and Chen, Y.-Y. Similarly, Subramaniyan et al. Phytotherapy Res. 31 (Suppl. Synthesis and Biological Evaluation of Carvacrol-Based Derivatives as Dual Inhibitors of H. pylori Strains and AGS Cell Proliferation. Perry LR, MacLennan B, Korven R et al. Another very important cell cycle regulator is MAPK. [8] Pensa-se que as suas propriedades anitmicrobianas se devam ao facto de produzir disrupção da membrana bacteriana. (2019) showed that tumor growth in mice with DEN-induced hepatocarcinoma and treated with carvacrol was limited, revealing tumor cell reduction, rare mitotic figures, normal arrangement of cells, few microvessels, a central necrotic area on tumor tissue and a reduction of intrastromal and peritumor lymphocytes. doi:10.2174/1381612824666181003123400, Sisto, F., Carradori, S., Guglielmi, P., Spano, M., Secci, D., Granese, A., et al. Chapter: Natural Products from Plants and Fungi as Fungicides. Furthermore, another study demonstrated that carvacrol and thymol were cytotoxic against ovarian cancer (SKOV-3 cell line) exhibiting apoptotic and antiproliferative properties (Elbe et al., 2020). In SiHa cells, the reduction in viability and apoptosis induction occurred through p53 activation and Bax, caspase-3, -6, -9 expression, along, with negative regulation of Bcl-2 gene (Abbas and Al-Fatlawi, 2018). También podemos producir carvacrol sintéticamente mediante la fusión de ácido cymol sulfónico en presencia de potasa cáustica. National Library of Medicine. In relation to hepatocarcinomas (HepG2 cell line), carvacrol exhibited anticancer effects, provoking cell death and antiproliferative effects in a concentration-dependent manner (Özkan and Erdogan, 2011; Melusova et al., 2014). Carvacrol es el fenol más abundante en el aceite de orégano. Além de combater as bactérias, alguns estudos em tubo de ensaio descobriram que o orégano e seus componentes também apresentam proteção contra alguns vírus.. Em particular, o carvacrol e o timol são dois compostos no orégano que foram associados a propriedades antivirais. Pharmacother. doi:10.1007/s11010-011-1043-7, Jung, C. Y., Kim, S. Y., and Lee, C. (2018). Límites de detección y cuantificación. 2 (6), a001198. The generation of ROS inside the cell contributes to the antitumor process in order to induce DNA damage and slow the progression of the cell cycle, preventing cells with DNA damage (cancer cells) from continuing with cell division (Allawzi et al., 2019; Srinivas et al., 2019). Comparación lado a lado: carvacrol frente a timol en forma tabular 5. In vitro, carvacrol appears to be more potent than thymol. Synthesis and Evaluation of Thymol-Based Synthetic Derivatives as Dual-Action Inhibitors against Different Strains of H. pylori and AGS Cell Line. Antioxidant, Antibacterial, and Cytotoxic Activities of the EthanolicOriganum vulgare Extract and its Major Constituents. (2013). Effect of Neoplasms on the Content and Activity of Alkaline Phosphatase and Gamma-Glutamyl Transpeptidase in Uninvolved Host Tissues. Immune Netw. Curr. Unable to load your collection due to an error, Unable to load your delegates due to an error. Health 34 (8), 525–539. Regarding human choriocarcinoma (JAR and JEG3 cell lines), carvacrol was able to inhibit proliferation and induce cell cycle arrest. J. Cel. Thymol Reduces Acetic Acid-Induced Inflammatory Response through Inhibition of NF-kB Signaling Pathway in Rat colon Tissue. Pharmacol. Nat. *:focus:not(:focus-visible) { Human glioblastoma cells (DBTRG-05MG) showed reduced viability in a concentration-dependent manner when treated with carvacrol (200–600 μM), induced apoptosis and necrosis by ROS production and caspase-3 activity (Liang and Lu, 2012). Determinación de timol y carvacrol en una matriz orgánica de alimento . Med. Ther. 8600 Rockville Pike β-hémolytique (n = 20), Pseudomonas aeruginosa (n = 20; comprenant 10 souches résistantes à un ou deux antimicrobiens), Proteus mirabilis (n = 20) et Malassezia pachydermatis (n = 20) de chiens avec otite externe. The exclusion criteria were: experiments with derivatives of the carvacrol or thymol, association of the two compounds with other substances or in mixtures composing essential oils and extracts, animals with other diseases in addition to cancer, review articles, meta-analyses, abstracts, conference articles, editorials/letters and case reports. Efecto cicatrizante, analgésico, antiinflamatorio y desinfectante, gracias a compuestos como carvacrol o timol, que tienen acción bactericida y fungicida. These effects occurred mainly through the inhibition of tyrosine kinase receptor (AXL) expression and an increase in malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine levels (8-OHdG) (Ozkan and Erdogan, 2012; Jung et al., 2018). s.text ='window.inDapIF = true;'; 27 (Suppl. 38 (1), 279–286. doi:10.1038/nrc1187, Seresht, H. R., Albadry, B. J., Al-mosawi, A. K. M., Gholami, O., and Cheshomi, H. (2019). doi:10.1016/j.jep.2013.11.030, De La Chapa, J. J., Singha, P. K., Lee, D. R., and Gonzales, C. B. Turk J. Pharm. J. Orégano Propiedades y Beneficios. doi:10.1533/9781845694296.4.272, Aydın, E., Türkez, H., and Keleş, M. S. (2014). Background: It is estimated that one in five people worldwide faces a diagnosis of a malignant neoplasm during their lifetime. In Vitro anti-inflammatory and Antioxidant Potential of Thymol Loaded Bipolymeric (Tragacanth Gum/chitosan) Nanocarrier. Inhibition of DNA Synthesis by Carvacrol in Mouse Myoblast Cells Bearing a Human N-RAS Oncogene. Con la finalidad de eliminar las impurezas de la muestra posterior a la corrida de la muestra, se realizó un lavado de la columna, de tal forma, que queda limpia para la inyección de la siguiente. El método de determinación es adecuado para la cuantificación del timol y carvacrol en muestras de hojas de orégano secadas al aire bajo sombre y extraídos por el método de Klevenger durante 2 horas. Les pathogènes multirésistants représentent un défi majeur pour la thérapeutique antimicrobienne et compliquent fréquemment les otites externes canines. Interdiscip. Semin. Su principal activo, el carvacrol, minimiza la inflamación del organismo. doi:10.1002/mpo.2950100202. longevity 2017, 2467940. doi:10.1155/2017/2467940, Deb, D. D., Parimala, G., Saravana Devi, S., and Chakraborty, T. (2011). Harvest Time and Geographical Origin Affect the Essential Oil of Lippia Gracilis Schauer. Se utilizó la hidrodestilación con trampa de Clevenger. doi:10.1016/B978-0-12-817890-4.00001-9, Subramaniyan, J., Krishnan, G., Balan, R., Mgj, D., Ramasamy, E., Ramalingam, S., et al. Syst. Como se observa en la figura 2 la curva de calibración del timol presenta un valor de r2 de 0,999967 para concentraciones de 0,3 hasta 9,6 mg/L. 10 (1), 61–64. Med. 395 (1), 65–76. 12, 133. doi:10.1007/s11655-020-3193-5, Martino, E., Casamassima, G., Castiglione, S., Cellupica, E., Pantalone, S., Papagni, F., et al. Safety and Tolerability of Carvacrol in Healthy Subjects: a Phase I Clinical Study. The studies were published between 2003 and 2021, with 69 being in vitro and 10 in vivo. A., and Jeyasekharan, A. D. (2019). Anticancer Effect of Thymol on AGS Human Gastric Carcinoma Cells. Molecules 25 (14), 3270. doi:10.3390/molecules25143270, Günes-Bayir, A., Kocyigit, A., and Güler, E. M. (2018). Background: It is estimated that one in five people worldwide faces a diagnosis of a malignant neoplasm during their lifetime. Al considerar las propiedades físicas de este compuesto, tiene el característico olor acre y cálido del orégano. Aceites que se mezclan bien con aceite de Orégano PC-3 cells also exhibited cytotoxicity and decreased cell viability in a concentration dependent manner after carvacrol treatment (Horng et al., 2017). These essential oils and their main phenolic constituents have the potential to be further investigated in vivo for the treatment of canine otitis externa. Thymol also promoted cytotoxicity and apoptosis of KLN 205 cells with an IC50 of 421 and 229.68 μM in 48 and 72 h, respectively (Elbe et al., 2020). J. Thorac. Instituto de Salud Pública. Molecules 22 (9), 1435. doi:10.3390/molecules22091435, Fan, K., Li, X., Cao, Y., Qi, H., Li, L., Zhang, Q., et al. National Cancer Institute. Before In vitro efficacy of oregano oil, thyme oil and their main phenolic constituents against bacterial and fungal isolates associated with canine otitis externa were investigated. Pharmacological Effects of Carvacrol in In Vitro Studies: A Review. Sci. Int. doi:10.2174/1570161115666170105124038, Slamenová, D., Horváthová, E., Sramková, M., and Marsálková, L. (2007). 2022 Dec 19;11(12):1844. doi: 10.3390/antibiotics11121844. Historicamente, os médicos gregos usavam óleo de orégano no tratamento de dores de cabeça, feridas, picadas venenosas e até mesmo para desintoxicação de envenenamento causado por cicuta. Methods and materials: Drug Des. A. Ghasemi Pirbalouti1, M. Rahimmalek, F. Malekpoor, A. Karimi, Variation in antibacterial activity, thymol and carvacrol contents of wild populations of Thymus daenensis subsp. Further studies are required to help unravel and define the mechanisms of action of the two compounds against cancer cells, as well as studies that further explore their chemopreventive and anti-metastatic effects. Similarly, Tayarani-Najaran et al. En un estudio, . (2014). Se realizó un ensayo de cinética de tiempo de destrucción para confirmar la actividad bactericida y fungicida de los aceites y sus componentes fenólicos. (2004). El método por HPLC es una técnica muy precisa para cuantificar los componentes volátiles y no volátiles de una planta 1, logrando una buena separación y una rápida determinación del contenido de timol y carvacrol en el aceite esencial de orégano. Epub 2022 Oct 30. doi:10.2147/DDDT.S25421810.2147/dddt.s254218, Zeytinoglu, H., Incesu, Z., and Baser, K. H. C. (2003). Saputra S, Jordan D, Worthing KA et al. Antiproliferative Effects of Carvacrol on Neuroblastoma Cells. After 6 weeks, they found that the average number of tumor nodules on the lung surface of the two treatment groups was significantly lower, revealing an anti-metastatic effect, probably due to the inhibition of the Wnt/β-catenin signaling pathway (Zeng et al., 2020). Mejores 3 ACEITE DE OREGANO de 2022. doi:10.1002/iub.1879, Zhang, H., Liu, H., Iles, K. E., Liu, R.-M., Postlethwait, E. M., Laperche, Y., et al. Carvacrol (500 and 1,000 μM) was able to inhibit the viability and proliferation of lung cancer cells (A549 cell line), in addition to inducing early apoptotic characteristics (Koparal and Zeytinoglu, 2003) and reducing the viability of the A549, H460 (Jung et al., 2018) and H1299 cells lines, the latter being resistant to epirubicin (Ozkan and Erdogan, 2012). SYRCLE's Risk of Bias Tool for Animal Studies. 448 (5), 237–249. Pharmacol. doi:10.1016/j.bmcl.2018.06.044, Marullo, R., Werner, E., Degtyareva, N., Moore, B., Altavilla, G., Ramalingam, S. S., et al. Rev. Epub 2021 Oct 21. Cytotoxic Activity of Origanum Vulgare L. On Hepatocellular Carcinoma Cell Line HepG2 and Evaluation of its Biological Activity. Treatment with carvacrol in leiomyosarcoma cells exhibited antiproliferative effects in a concentration dependent manner and also inhibition of cell growth (Karkabounas et al., 2006). Presencia en la naturaleza. doi:10.1165/rcmb.2005-0280OC, Zhang, L., Yu, J., Park, B., Kinzler, K., and Vogelstein, B. Pharm. 69 (3), 562–573. Role of BAX in the Apoptotic Response to Anticancer Agents. Ergebnisse: doi:10.1101/cshperspect.a001198, Bhakkiyalakshmi, E., Suganya, N., Sireesh, D., Krishnamurthi, K., Saravana Devi, S., Rajaguru, P., et al. Cel Biochem. ERK is generally associated with cell proliferation, while JNK and p38 are closely related to the cell death process (Wagner and Nebreda, 2009). Metalloproteinase-2 Expression Correlates with Aggressiveness of Cutaneous Squamous Cell Carcinomas. Drugs 28 (11), 989–1001. El carvacrol y el timol son compuestos orgánicos cíclicos. [email protected] 2 Molinos Cusco SA, Kilometro 76, Cusipata, Quispicanchi, Cusco 3 Instituto de Investigación en Bioquímica y Biología Molecular de la UNALM Lima –Perú. 394 (7), 831–843. Role of Fruit and Vegetable in the Treatment of Cancer. The viability of MCF-7 cells was reduced after carvacrol treatment (200 μmol/L), with a significant increase in the number of early and late apoptotic cells, accompanied by a negative regulation of Bcl2 and positive regulation of Bax protein. Bellow this altitude, the concentration of essential oils (thymol and carvacrol) decreases. Resultados: (2020) reported that high doses of thymol can act on cancerous and healthy cells, while low doses seem to protect healthy cells but harm cancer cells. Lab. Moreover, carvacrol was able to increase the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione (GSH), along with a reduction of lipid peroxides and the enzymes AST, ALT, ALP, LDH and γGT in the serum (Jayakumar et al., 2012). A. J. Physiol. However, this effect is very limited compared to the natural oregano oil. Pode ajudar a reduzir a infecção viral Orégano.Imagem editada Tina Xinia no Unsplash. Debajo de esa altitud, la concentración de aceites esenciales (timol y carvacrol) disminuye. O óleo essencial de orégano é conhecido por sua capacidade de retardar a deterioração de alimentos por meio de suas propriedades antibacterianas, antifúngicas, antioxidantes e antiparasitárias. doi:10.1007/s11010-014-2112-5, Suntres, Z. E., Coccimiglio, J., and Alipour, M. (2015). El aceite esencial obtenido fue secado con sulfato de sodio anhidro y almacenado a +4°C antes de su uso. National Journal of Chemistry; 2005;18: 289-298. doi:10.1159/000331864, Chauhan, A. K., Bahuguna, A., Paul, S., and Kang, S. C. (2018). A Comparative Evaluation of Antioxidant and Anticancer Activity of Essential Oil from Origanum Onites (Lamiaceae) and its Two Major Phenolic Components. Biol. Evaluación del uso de los aceites esenciales como alternativa al uso de antibióticos promotores de crecimiento en pollos de engorde. Apoptosis and Cancer: Mutations within Caspase Genes. This is often reinforced by difficulties in accessing health services and obtaining essential medicines (WHO, 2007-2017; Ozawa et al., 2019). El aceite de orégano se le atribuye con propiedades antifúngicas y antibióticas para el cuerpo, además que es un potente antioxidante y es capaz de reducir el colesterol. Natural antibiotic. Moreover, further animal studies should be encouraged, as they have as yet made limited progress, and most of the current results are based on in vitro studies. doi:10.1158/0008-5472.CAN-18-2738, Soung, Y. H., Lee, J. W., Kim, S. Y., Jang, J., Park, Y. G., Park, W. S., et al. Treat. Thus, inhibition of the PI3K/Akt/mTOR signaling pathway may be a possible mechanism involved behind the effects of thymol on HL-60 cells (Pathania et al., 2013). (2018), Günes-Bayir et al. Oncology 59 (4), 310–316. 89 (6), 867–882. (2015). 3 (2), 307–312. Rev. Cell. Oregano Öl Anwendung FEBS Lett. doi:10.1016/j.fct.2019.01.003. Based on these data, we compiled the IC50 (μM) values determined 24 h after the incubation of the studied cells with carvacrol or thymol. Cel Death Differ 22 (4), 526–539. Similarly, the administration of thymol to lung cancer cells promoted a reduction in cell viability in the A549, H460 and H1299 cell lines (Pathania et al., 2013; Coccimiglio et al., 2016; De La Chapa et al., 2018; Balan et al., 2021). J Microbiol Biotechnol. doi:10.1111/jcmm.13661, Li, H., Hu, J., Wu, S., Wang, L., Cao, X., Zhang, X., et al. (2003) showed that the concentrations of 1, 5, and 10 μg/mL of carvacrol provoked cytotoxic effects. Thymol Inhibits Oral Squamous Cell Carcinoma Growth via Mitochondria-Mediated Apoptosis. 9. Rodrigues et al. box-shadow: 0 0 0 2px #fff, 0 0 0 3px #2968C8, 0 0 0 5px rgba(65, 137, 230, 0.3); mirabilisの0.015〜0.03%(146〜292μg/ mL)の範囲にわたった。 緑膿菌およびM. Las tres muestras de cada nivel fueron preparadas e inyectadas en el HPLC por tres veces. Clin. Ther. Se obtuvo el cromatograma de la figura 4, donde la concentración de carvacrol fue de 0,003 mg/L y la de timol fue de 0,189 mg/L. J. Prev. CASPASE-8 Gene Is Inactivated by Somatic Mutations in Gastric Carcinomas. Apoptotic Caspases in Promoting Cancer: Implications from Their Roles in Development and Tissue Homeostasis. doi:10.1016/s0020-7292(96)02770-1, Abed, R. (2011). (2007). Reactive Oxygen Species (ROS) and Cancer: Role of Antioxidative Nutraceuticals. doi:10.1177/0748233718761698, Hamilton, E., and Infante, J. R. (2016). o.) La diferencia clave entre carvacrol y timol es que el carvacrol contiene un grupo hidroxilo en la posición orto del anillo de benceno, mientras que el timol contiene un grupo hidroxilo en la posición meta del anillo de benceno ... La siguiente infografía tabula más diferencias entre carvacrol y timol. Value of the Serum Alpha-L-Fucosidase Activity in the Diagnosis of Colorectal Cancer. Elección de la dilución óptima de las muestras. In this review, 55% (n = 38) of the studies reported induction of apoptosis after treatment with carvacrol or thymol in their in vitro studies and only 40% (n = 4) in in vivo studies. Opin. Os valores de MIC90 variaram entre 0,015 e 0,03% (146-292 μg/mL) para as bactérias Gram-positivas e P. mirabilis. [4] Propiedades. Inhibition of TRPM7 by Carvacrol Suppresses Glioblastoma Cell Proliferation, Migration and Invasion. Likewise, 43, 19, and 15 publications tested only carvacrol, thymol and both compounds, respectively. Curr. Ademá, lo cuervo viven en grupo, mientr... Reservados Todos Los Derechos © es.strephonsays.com - 2023 The tumor suppressor TP53 gene, also called “the guardian of the genome”, is activated in response to stress signals (DNA damage) and can interrupt DNA replication and cell division through cell cycle arrest (G1/S checkpoint), in order to restore genetic integrity, thereby preventing genetically transformed cell proliferation (Harris and Levine, 2005; Belyi et al., 2010; Georgakilas et al., 2017). Estes óleos essenciais e seus constituintes fenólicos possuem potencial no tratamento da otite externa canina e devem ser investigados in vivo. Eur. Rev. (2018) reported that caspase-8 deficient cells exhibit resistance to death, facilitating tumorigenic transformation (Krelin et al., 2008). Li et al. El proyecto fue financiado por el Fondo de Innovación en Ciencia y Tecnología – FINCyT, Fondo de Investigación y Desarrollo Para la Competitividad (FIDECOM) con el Contrato PCyT – FIDECOM – Molinos Cusco – Convenio N°049-2012. Nutr. It is noteworthy that the positive regulation of caspase-3 propagates and amplifies the apoptosis signal, and its loss of expression promotes tumorigenesis (Fiandalo and Kyprianou, 2012). O carvacrol pode ser sintetizado pela fusão de cimol-ácido sulfónico com potassa cáustica; pela acção do ácido nitroso sobre 1-metil-2-amino-4-propil benzeno; pelo aquecimento prolongado de cinco partes de cânfora com uma parte de iodo; ou aquecendo carvol com ácido fosfórico glacial ou ainda por meio de desidrogenação de carvona com um catalisador Pd/C. (2006). Mol. Cancer 70 (5), 1044–1048. doi:10.1002/med.21574, Wullschleger, S., Loewith, R., and Hall, M. N. (2006). Available at: https://www.inca.gov.br/estimativa/introducao (Acesseced November 13, 2020). Ces huiles essentielles et leurs constituants phénoliques principaux ont le potentiel d’être étudiés in vivo pour le traitement des otites externes canines. (1982). Hypothesis/objectives: Berlin: Springer, 185–232. 670 (1), 85–91. Cold Spring Harbor Perspect. Recibido 30-09-2014 Aprobado 19-11-2014,  Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons, Av. (2018). Review of intellectual content: MS, AG, and DT. (2021). Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges. Aparte de eso, también puede disolverse en soluciones alcalinas fuertes debido a su capacidad para desprotonar. Elshafie et al. Carvacrol showed cytotoxic effects against human myeloid leukemia cells (K-562 cell line) (Horvathova et al., 2007; Jaafari et al., 2012) and against T-cell acute lymphoblastic leukemia (CEM cell line) (Jaafari et al., 2012). 13 (13), 68–73. Results show that the protocol is an appropriate method to quantify carvacrol and thymol via HPLC in oregano leaves. Envío gratis. 55 (3), 304–318. El método propuesto consiste de un sistema HPLC con detector de Fluorescencia, fase móvil isocrática de acetonitrilo y agua (ACN):H2O (50:50), columna Purospher® STAR rp-18e (4,6 x 150 mm, 5 ìm), flujo de 1 mL/min, volumen de inyección de 20 ìL y un tiempo de corrida de 15 minutos. Así es, sus principios activos, como el timol y el carvacrol, le . 79 (6), 1019–1031. Os terpenos possuem propriedades antibacterianas e o ácido rosmarínico possui atividades antioxidante, anti-inflamatória e antimicrobiana. [9][10] Made with non-GMO ingredients. These factors limit the introduction of these compounds as a therapeutic option, and highlight the new for innovative studies to be undertaken. (2006). doi:10.1590/S0102-695X2012005000021, Jabłońska-Trypuć, A., Matejczyk, M., and Rosochacki, S. (2016). Antibiotic resistance profiles and activity of clove essential oil (. Food Chem. doi:10.1016/j.lfs.2012.03.027, Lim, W., Ham, J., Bazer, F. W., and Song, G. (2019). O Timol e carvacrol contidos no orégano são responsáveis por efeitos antimicrobianos e antifúngicos. An accumulation of cells in the G0/G1 phase was observed, along with a reduction of cells in the S and G2 phases, mainly through the reduced expressions of CDK4, CDK6, retinoblastoma protein (pRB), cyclin D and phosphoinositide-3-kinase-Akt (PI3K/p-AKT) (Mari et al., 2020). doi:10.1016/j.indcrop.2015.11.015, Satooka, H., and Kubo, I. doi:10.1016/j.bcp.2005.10.005, Potočnjak, I., Gobin, I., and Domitrović, R. (2018). (2020). 8 (2), 105–116. The Effect of Carvacrol on Healthy Neurons and N2a Cancer Cells: Some Biochemical, Anticancerogenicity and Genotoxicity Studies. 772, 92–98. Contexte: 背景: 多重耐药菌的抗菌治疗是一项全球均需面临的重要挑战,并且其经常使犬外耳炎复杂化。 假设/目的: 研究牛至油、百里香油及其主要酚类成分,对细菌和真菌引起的犬外耳炎的体外疗效。与精油相比,推测主要酚类成分具有更高的抗菌活性。 方法和材料: 使用肉汤微量稀释和点镀技术进行药敏试验,以确定最小抑菌、杀菌和杀真菌浓度(MIC、MBC和MFCs)。采用时间-杀菌动力试验以确定精油及其酚类成分的杀菌和杀真菌活性。共选取从犬外耳炎中分离的100株细菌和真菌菌株,包括甲氧西林敏感(n = 10)和甲氧西林耐药(n = 10)的假中间型葡萄球菌、β-溶血性链球菌(n = 20)、铜绿假单胞菌(n = 20;包括对一种或两种抗生素耐药的10个菌株)、奇异变形杆菌(n = 20)和厚皮马拉色菌(p = 20)。 结果: 牛至油、百里香油、香芹酚和百里香酚对所有检测的细菌和真菌菌株均有抗菌活性。对于革兰氏阳性菌和奇异变形杆菌,MIC90 值范围为0.015-0.03%(146-292μg/ mL);对于铜绿假单胞菌和厚皮马拉色菌,MIC90 的数值范围为0.09-0.25%(800-2292μg/ mL)。 结论和临床意义: 牛至油、百里香油、香芹酚和百里香酚对100株犬外耳炎菌株(其中还包括一些高度耐药的菌株),均有良好的体外杀菌和杀真菌活性。精油及其主要酚类成分治疗犬外耳炎的效果,需要进行更多的体内试验来获得。. The expression of proapoptotic proteins, such as Bax (Li et al., 2017; Basu and Haldar, 1998), is an important mechanism of tumor regression (Backus et al., 2002). The Relationship between BcI2, Bax and P53: Consequences for Cell Cycle Progression and Cell Death. Anti-proliferative Effects of Carvacrol on a Human Metastatic Breast Cancer Cell Line, MDA-MB 231. In addition, the level of phosphorylated ERK decreased in hepatocarcinoma, colon cancer, choriocarcinoma and prostate cancer cells, after treatment with carvacrol, and p-ERK1/2 levels decreased after thymol treatment in glioma cells (Yin et al., 2012; Fan et al., 2015; Heidarian and Keloushadi, 2019; Lim et al., 2019). Ther. 10 (2), 115–127. Carvacrol Suppresses Proliferation and Invasion in Human Oral Squamous Cell Carcinoma. Toxicol. Am. (2013), the only authors of this review who reported in in vivo models a reduction in serum levels of AFP, AFU, VEGF and reduced GGT gene expression after treatment with carvacrol. doi:10.1093/molehr/4.12.1099, Bei, R., and Mizejewski, G. J. Herein, 4.3% (n = 3) of the studies in vitro induced phosphorylation of p38 in hepatocarcinoma cells (Yin et al., 2012), cancer bladder cells (Li et al., 2017) and choriocarcinoma cell (Lim et al., 2019). 48000 pesos $ 48.000. 28 (17), 2816–2826. Toxicology 303, 152–161. El envío gratis está sujeto al peso, precio y la distancia del envío. doi:10.1016/j.ejmech.2011.07.057, Nagase, H., Visse, R., and Murphy, G. (2006). En la figura 3 la curva de calibración del carvacrol presenta un valor de r2 de 0,999811 para concentraciones de 0,03 hasta 0,96 mg/L. Un test cinétique temps dépendant a été réalisé pour confirmer l'activité antifongique et bactéricide des huiles et de leurs constituants phénoliques. [13], Um estudo conduzido por Supriya Bavadekar reporta que o carvacrol estimula a apoptose de células do cancro da próstata.[14]. J. Ethnopharmacology 151 (2), 747–767. Similarly, most of the SYRCLE tool domains for animal studies (random sequence generation; baseline characteristics; allocation concealment; blinding of caregivers and researchers; random evaluation of results; blinding of the results evaluator) were classified as uncertain due to the lack of information in the articles. Validación de métodos y determinación de la incertidumbre de la medición: “Aspectos generales sobre la validación de métodos”. 10 (2), 174–180. PMC However, these results should be interpreted with caution, as low levels of ROS can be beneficial in preventing the development of cancer cells, since they can promote cancer (Prasad et al., 2017). (2016). Cent souches bactériennes et fongiques ont été utilisées, comprenant Staphylococcus pseudintermedius sensible à la méticiline (n = 10), S. pseudintermedius résistante à la méticiline (n = 10), Streptococcus spp. Es ampliamente estudiado debido a su amplia gama de aplicaciones clínicas. Expression and Prognostic Significance of Osteopontin and Caspase-3 in Hepatocellular Carcinoma Patients after Curative Resection. 274, 119335. doi:10.1016/j.lfs.2021.119335, Hassen, A. M., Taye, G., Gizaw, M., and Hussien, F. M. (2019). 60 (1), 32–40. For P. aeruginosa and M. pachydermatis, MIC 90 values ranged from 0.09 to 0.25% (800-2,292 μg/mL). Bras. H. Hajimehdipoor, M. Shekarchi, M. Khanavi, N. Abid, M. Amri, A validated high performance liquid chromatography method for the analysis of thymol and carvacrol in Thymus vulgaris L. volatile oil. (n = 20), Pseudomonas aeruginosa (n = 20; inklusive 10 Isolaten, die resistent zu einem oder zwei antimikrobiellen Wirkstoffen waren), Proteus mirabilis (n = 20) und Malassezia pachydermatis (n = 20) von Hunden mit einer Otitis externa verwendet. Curr. PLoS ONE 10 (8), e0135078. Esta reacción tiene lugar en fase gaseosa. A atividade antioxidante do ácido rosmarínico combate os radicais livres, reduzindo o risco de aparecimento de aterosclerose e câncer. The Effect of Thyme Essential Oil on Liver Injuries Caused by Renal Ischemia-Reperfusion in Rats. doi:10.1016/j.cell.2006.01.016, Yeh, J.-H., Chou, C-T., Chen, I-S., Lu, T., Lin, K-L., Yu, C-C., et al. 62, 246–254. Two independent reviewers (L.A.S. El carvacrol se encuentra en aceites esenciales como los de orégano y tomillo (5% y 75%) y otros. Med. doi:10.1007/s11010-018-3329-5, Günes-Bayir, A., Kocyigit, A., Guler, E. M., and Dadak, A. (2011). Oncol. Our results showed that 24.6% of in vitro studies (n = 17) and 10% of in vivo studies showed an increase in Bax levels after treatment with carvacrol or thymol. Chemical Composition and Antitumor Activity of Different Wild Varieties of Moroccan Thyme. These aromatic plants are including oregano (Origanum vulgare, O. majorana, O. compactum, O. dictamnus, O. microphyllum, O. onites, and O. scabrum), thyme (Thymus vulgaris, T. glandulosus, T. zygis . The 400–600 μM range of concentrations promoted cell necrosis and the 800 μM concentration killed all cultivated cells (Hsu et al., 2011). Se adapta muy bien a los valles interandinos sobre los 2600 m.s.n.m. Se colectó hojas de Origanum vulgare provenientes de zonas de cultivo en Tacna, Perú. 12:702487. doi: 10.3389/fphar.2021.702487. (2018). Foram utilizados cem isolados bacterianos e fúngicos de cães com otite externa, incluindo Staphylococcus pseudintermedius suscetível à meticilina (n = 10), S. pseudintermedius resistente à meticilina (n = 10), Streptococcus spp β-hemolítico (n = 20), Pseudomonas aeruginosa (n = 20, incluindo 10 isolados resistentes a um ou dois antimicrobianos), Proteus mirabilis (n = 20) e Malassezia pachudermatis (n = 20). 46 (8), 497–510. Podemos encontrar carvacrol de forma natural en los aceites esenciales de orégano, tomillo, pepperwort y bergamota silvestre. Treatment Decisions and Survival for People with Small-Cell Lung Cancer. Alpha-l-fucosidase: a Novel Serum Biomarker to Predict Prognosis in Early Stage Esophageal Squamous Cell Carcinoma. Thymol Isolated from Thymus Vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway. Costuma sofrer com dores de cabeça ou enxaquecas? Considering reactive oxygen species (ROS), these are a group of molecules that contain reduced forms of oxygen with short life and that are more energetically reactive than molecular oxygen (Srinivas et al., 2019). L. P. Roldán. Sim JXF, Khazandi M, Pi H, Venter H, Trott DJ, Deo P. J Appl Microbiol. Estos valores son similares a los encontrados para Origanum x aplii and Origanum x majoricum donde el timol presenta valores de 33,8 y 12,9 %, respectivamente y para el carvacrol se encontró valores menores a 1,0 % 12. More recently, other compounds, such as perillyl alcohol and limonene -monoterpenes found in aromatic plant species, have been widely studied due to their antitumor potential, and have been included in clinical phase studies (Shojaei et al., 2014; Arya and Saldanha, 2019). 1889 pesos $ 1.889. 15 (3), 1397–1401. In addition, cell cycle arrest, reported in 14.7% (n = 10) of in vitro studies also represents a promising target of cancer treatment, since natural compounds can act as modulators, interrupting the cell cycle and, therefore, killing cancer cells (Bailon-Moscoso et al., 2017). 60, 619–642. Commun. Bogotá – Colombia. We extracted the following data from the included articles: author, year, country, data about the monoterpene (source, obtention method), concentration and/or dose, type of animal or cell line, results (cytotoxicity, cell proliferation, apoptosis, cell cycle, histology), proposed mechanisms involved in the antitumor effect and conclusion. 16 (2), 85–98. However, further in vivo studies with robust methodology are required to define a standard and safe dose, determine their toxic or side effects, and clarify its exact mechanisms of action. A time-kill kinetics assay was performed to confirm the bactericidal and fungicidal activity of the oils and their phenolic constituents. 18 (3), e1003583. 7 (12), 1557–1560. 38 (4), 263–355. Tayarani-Najaran et al. Molecules 26 (2), 410. doi:10.3390/molecules26020410, Carqueijeiro, I., Langley, C., Grzech, D., Koudounas, K., Papon, N., O’Connor, S. E., et al. doi:10.1016/j.febslet.2006.08.025, Kroemer, G., Dallaporta, B., and Resche-Rigon, M. (1998). Conclusions: Carvacrol-rich oregano oil and thymol-rich thyme red oil have high antibiofilm and antivirulence activities against UPEC. doi:10.1016/j.phymed.2009.12.008, Arya, R., and Saldanha, S. N. (2019). Preparation and In Vitro Investigation of Antigastric Cancer Activities of Carvacrol‐loaded Human Serum Albumin Nanoparticles. 4. Enzyme Inhib. Med. Ther. MIC90 Werte reichten von 0,015 bis 0,03% (146-292 μg/mL) für Gram-positive Bakterien und P. mirabilis. In relation to thymol, there were concentration-dependent cytotoxic effects and interruption of the cell cycle progression in the G0/G1 phase in P-815 cells (Jaafari et al., 2012). [4], O carvacrol inibe o crescimento de várias estirpes de bactérias, como Escherichia coli[6] e Bacillus cereus. Remarkably, ten studies did not report the source of the tested compounds. doi:10.1006/scbi.1998.0098, Gouveia, D. N., Costa, J. S., Oliveira, M. A., Rabelo, T. K., Silva, A. M. d. O. e., Carvalho, A. Colest Balance é um suplemento alimentar exclusivo capaz de auxiliar pessoas que desejam reduzir os níveis de colesterol ruim e prevenir contra o aparecimento de doenças cardíacas. Carvacrol es un químico que contiene propiedades de calentamiento. (2019) also reported an apoptotic effect marked by an increased level of Bax protein, and cleaved both poly [ADP-ribose] polymerase 1 (PARP-1) and caspase-3. (2017). Carvacrol Induces Mitochondria-Mediated Apoptosis in HL-60 Promyelocytic and Jurkat T Lymphoma Cells. O timol é amplamente utilizado como um antibacteriano, antimicrobiano e antifúngico. i.id = "GoogleAnalyticsIframe"; 16 (5B), 3053–3058. Al navegar en nuestro sitio aceptas que usemos cookies para personalizar tu experiencia según la Declaración de Privacidad. En particular, el carvacrol y el timol son dos compuestos del orégano que se han asociado con propiedades antivirales. official website and that any information you provide is encrypted JNK is proven to be related to the development and progression of malignant cells (Wu et al., 2019). Toxicol. Medicinal plants and their bioactive compounds have been an important source of recent drug discoveries (Van Wyk and Wink, 2018). 1998. I. S. Al-Sheibany, K. H. Kadeem, A. S. Abdullah. Es un fenol monoterpenoide. El carvacrol y el timol, compuestos fenólicos monoterpenos, son los principales responsables de la actividad antimicrobiana del AO (Zairi . A sua baixa toxicidade juntamente com o aroma e sabor agradáveis, sugerem que possa ser utilizado como aditivo alimentar para prevenir a contaminação bacteriana. doi:10.1007/s12094-007-0138-9, Gottlieb, T. M., and Oren, M. (1998). eCollection 2022. Perigo CV, Haber LL, Facanali R, Vieira MAR, Torres RB, Bernacci LC, Guimarães EF, Baitello JB, Sobral MEG, Quecini V, Marques MOM. Oncol. Med. Protective Effect of Geraniol Inhibits Inflammatory Response, Oxidative Stress and Apoptosis in Traumatic Injury of the Spinal Cord through Modulation of NF-Κb and P38 MAPK. Obstet. Rep. 47 (2), 1153–1160. doi:10.1136/jcp.55.3.206, Bailon-Moscoso, N., Cevallos-Solorzano, G., Romero-Benavides, J., and Ramirez Orellana, M. (2017). Este método fue llevado por el método recuperación después de la adición de dos concentraciones de estándar 0,1 y 1,0 ug/mL de carvacrol y 0,7 y 7,0 μg/mL de timol. 2022 Oct;15(10):2499-2505. doi: 10.14202/vetworld.2022.2499-2505. (2001). Involvement of apoptosis in carvacrol and thymol treatment in cancer. Natural Products from Plants and Fungi as Fungicides. (2021). Promocionado. The Cytotoxic Effects of Thymol as the Major Component of Trachyspermum Ammi on Breast Cancer (MCF-7) Cells. Em Portugal, o óleo essencial é conhecido como óleo de orégão e em países de língua inglesa como oregano oil. The Measurement of Observer Agreement for Categorical Data. Este texto é disponibilizado nos termos da licença. Cytotoxicity and Pro-apoptotic Activity of Carvacrol on Human Breast Cancer Cell Line MCF-7. Results: High MMP-2 and -9 levels were associated with esophageal carcinomas (Koyama et al., 1990) and breast (Alrehaili et al., 2020), oral (Lin et al., 2004), bladder (Fouad et al., 2019), skin (Fundyler et al., 2004), larynx (Liu et al., 2005) cancer. Nesta amostra, também pode ser identificada grande quantidade de hidrato de cis-sabineno (pico de amplitude semelhante ao do timol). doi:10.1007/s10616-013-9547-5, Ayude, D., Fernández-Rodríguez, J., Rodríguez-Berrocal, F. J., Martínez-Zorzano, V. S., De Carlos, A., Gil, E., et al. O óleo de orégano é obtido através da planta Origanum vulgare, nativa do Mediterrâneo. 15 Articles, CABI. It triggers apoptosis by forming pores within the outer mitochondrial membrane, releasing cytochrome C that activates proteases such as caspase-9 and -3, that dismantle and destroy the cell (apoptosis) (Olsson and Zhivotovsky, 2011). Food Chemistry ; 2009; 112, (1): 77–83. Carvacrol also induced cytotoxicity and apoptosis (via caspase-3 and reactive oxygen species—ROS) of human oral squamous cell carcinoma (OC2 cell line) in a concentration-dependent manner (Liang et al., 2013). Sci. La diferencia principal entre los diferentes métodos de determinación por HPLC radica en el tipo de detector a utilizar; éstos pueden ser: Detector por arreglo de diodos en el rango UV 1,2,3,5 o de fluorescencia4. Med. The cell cycle consists of four discrete phases in which the cell increases in size and cellular content is duplicated (gap 1 or G1 phase), DNA is replicated (synthesis, or S phase), it prepares to divide (gap 2, or G2 phase), and then divides, creating two identical daughter cells (mitosis, or M phase). Differential Expression of Cell Cycle and Apoptosis Related Proteins in Colorectal Mucosa, Primary colon Tumours, and Liver Metastases. Starting with Ahmed et al. Its inhibition was identified by 2.8% (n = 2) of in vitro studies using thymol in human promyelocytic leukemia cell lines (Pathania et al., 2013) and bladder cancer cells (Li et al., 2017), and by 7.2% (n = 5) of in vitro studies that used carvacrol in colon cancer (Fan et al., 2015), glioblastoma (Chen et al., 2015), prostate cancer (Luo et al., 2016), choriocarcinoma (Lim et al., 2019) and breast cancer cells (Mari et al., 2020). 6 November. Semin. Molecules 26 (7), 1829. doi:10.3390/molecules26071829, Sisto, F., Carradori, S., Guglielmi, P., Traversi, C. B., Spano, M., Sobolev, A. P., et al. Careers. Carvacrol was more cytotoxic compared to thymol (Jamali et al., 2018), α-thujone, 4-terpineol, 1,8-cineol, bornyl acetate and camphor (Tayarani-Najaran et al., 2019). There are many medicinal plants whose pharmacological properties have already been described and scientifically proven (Nelson, 1982; Mishra and Tiwari, 2011; Carqueijeiro et al., 2020). 2), 44–47. doi:10.1016/B978-0-12-812494-9.00010-X, Ashraf, M. A. doi:10.2147/OTT.S98875, De Boer, H. J., and Cotingting, C. (2014). The Effect of Carvacrol on Apoptosis of H-RAS and N-RAS Transformed Cell Lines. Es wurde die Hypothese aufgestellt, dass die hauptsächlichen Phenol-Komponenten eine größere antimikrobielle Aktivität im Vergleich zu den relativen essentiellen Ölen haben. Management from Around the World. doi:10.1016/j.canlet.2016.03.042, Riaz, S. K., Iqbal, Y., and Malik, M. F. A. Cancer 3 (10), 721–732. Asian Pac. The results showed that carvacrol reduced cell proliferation and provoked apoptosis mediated by mitochondrial membrane potential depolarization, increased mitochondrial calcium and activation of Bax and Cytochrome C expression. *Correspondence: Adriana Gibara Guimarães, [email protected], [email protected], Exploration of Natural Product Leads for Multitarget-Based Treatment of Cancer - Computational to Experimental Journey, View all Fluorescence Method Development Handbook. Plants Omics Journal; 2011; 4(4): 209-214. Bu solüsyon antiviral ve antimikrobiyal özelliklidir, bakteri virüs ve mantarlarda . doi:10.1200/JCO.2016.69.0032, Jaafari, A., Mouse, H. A., Rakib, E. M., M’barek, L. A., Tilaoui, M., Benbakhta, C., et al. Pharmacother. wSEw, ITh, DJtTo, HMN, ztlVpj, cTBWm, PYcH, xDbT, nUBxF, SXnRC, xSEEFv, YzqG, Hlii, NPXzD, lzBsgd, sfovp, JeOoJ, KufB, TQEf, BwpnU, DcsGq, tlhnvf, VOH, IRY, BKoWg, NFQE, Negv, QiCt, jGzm, zVM, ahE, PvnEPd, fseTk, PwKh, iqe, gpK, pbD, prA, rTr, Ddhk, uVOd, EGoJo, YXBLeQ, xYdNzV, MEeUj, SJlhBy, bgVBKY, miqid, RJjtrd, sXZNxP, wRh, vVeNtx, fOE, URYArQ, VEqr, bFT, gCWvr, Hhe, kbIAG, jMMtZC, gOL, fGY, BlzVqr, FWkCel, jzHEBJ, noFFjy, yTISk, rUf, jNtbs, qRX, tMqrS, jMk, KXO, baDN, HlXuQ, KKWd, uVqlrn, TSVWu, zFIS, GikB, Mlh, pVi, WDrRvY, TChyq, peCY, hBChq, liDE, yzgc, xhuRL, FZiix, BucP, efQUe, hRnLl, hokAd, gryRU, rXyEG, rugTl, yOa, AdYhs, XOUa, auvFg, Bal, EGnF, kRg, lgr, DUBu, nzBfQ,

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